Primark, the owner of the Penneys chain, is to transfer 220 roles to Dublin from its UK office in Reading by September.
The company says the move is not in any way related to Brexit, but is about an internal reorganisation that will involve the consolidation of teams in different locations.
Those currently in the jobs in Britain will be offered the opportunity to relocate, or to explore other possibilities including commuting or alternative roles.
The business said that redundancies would be a last resort.
Those impacted by the decision are primarily in buying, merchandising, design, quality and sourcing positions.
The company’s buying hub is based at its international headquarters in Dublin.
In a statement the firm said it continually reviews its operations for efficiency and optimisation to support its growth as an international retailer.
It said the changes are are part of Primark’s ongoing strategic focus to develop the product model to be more closely aligned with its customers’ needs.
"This change will ensure our business strategy and our expansion into new international markets is fully supported," said Paul Marchant, CEO of Primark.
It added that the Reading office will continue to employ 270 people and will play a "vital role" in its business.
Employing 75,000 people, Primark currently has 365 stores across eleven countries, including 37 here in Ireland.
Founded in Dublin in 1969, the company is currently owned by Associated British Foods.